Symbol
Name
ID

Tyk2
tyrosine kinase 2
MGI:1929470

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgE level	Immunodeficiency	Recurrent mycobacterial infections	Recurrent fungal infections	Recurrent respiratory infections	Recurrent viral infections
Disease(s) Associated with TYK2
immunodeficiency 35

Mouse Phenotypes

enlarged thymus

enlarged spleen

abnormal T cell differentiation

decreased plasmacytoid dendritic cell number

decreased IgG1 level

decreased IgG2a level

decreased IgG level

abnormal T cell physiology

abnormal T-helper 1 physiology

decreased macrophage nitric oxide production

abnormal splenocyte physiology

increased circulating interleukin-12 level

decreased interferon-gamma secretion

decreased susceptibility to induced arthritis

abnormal response to infection

increased susceptibility to viral infection induced morbidity/mortality

increased susceptibility to Herpesvirales infection induced morbidity/mortality

increased susceptibility to Riboviria infection induced morbidity/mortality

increased susceptibility to Picornaviridae infection induced morbidity/mortality

increased susceptibility to parasitic infection

increased susceptibility to Herpesvirales infection

increased susceptibility to Riboviria infection

Availability

Mouse Genotype

Tyk2^E775K/Tyk2^E775K

Tyk2^tm1Biat/Tyk2^tm1Biat

Tyk2^tm1Shmd/Tyk2^tm1Shmd

Tyk2^{tm2b(EUCOMM)Hmgu}/Tyk2^{tm2b(EUCOMM)Hmgu}

Tyk2^tm3.1Biat/Tyk2^tm3.1Biat

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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